Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8009424 | 1.00 | CYP3A4 (0.54) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL8002856 | 1.00 | CYP3A4 (0.54) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL4591245 | 1.00 | CYP3A4 (0.54) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL6918646 | 0.88 | CYP1A2 (0.47) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL8004084 | 0.85 | OPRD1 (0.37) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL8002904 | 0.81 | OPRD1 (0.34) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL8009013 | 0.81 | OPRD1 (0.34) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL8004080 | 0.81 | OPRD1 (0.34) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL9212660 | 0.81 | KDM4E (0.41) | CYP3A4CYP1A2OPRD1CYP2C9HPGD | |
| SCHEMBL6915923 | 0.81 | OPRD1 (0.43) | CYP3A4CYP1A2OPRD1CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1003373-A4 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS INC (US) | 2000-09-20 | — | — | EP | disclosed |
| EP-1003373-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 2000-05-31 | — | — | EP | disclosed |
| WO-1999001033-A1 | COMPOSITIONS AND METHODS FOR REDUCING RESPIRATORY DEPRESSION AND ATTENDANT SIDE EFFECTS OF MU OPIOID COMPOUNDS | DELTA PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |