Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | MAP3K8 | P41279 | 10/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCH | P24723 | 1/20 | 0.32 |
| ▸ | PRKCI | P41743 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691469 | 0.86 | PTK2 (0.44) | GAATSHRPTK2NPC1LMNA | |
| SCHEMBL691451 | 0.84 | MAPK1 (0.38) | GAATSHRPTK2MAPK1RPS6KA1 | |
| SCHEMBL691926 | 0.84 | PTK2 (0.52) | PTK2MAP3K8MAPK1RPS6KA1SRC | |
| SCHEMBL691211 | 0.83 | PTK2 (0.44) | GAAPTK2MAPK1RPS6KA1 | |
| SCHEMBL691073 | 0.81 | GAA (0.46) | GAATSHRPTK2MAP3K8SRC | |
| SCHEMBL1293073 | 0.75 | PTK2 (0.47) | PTK2MAPK1 | |
| SCHEMBL692860 | 0.73 | PTK2 (0.59) | GAAPTK2MAPK1RPS6KA1SMN1; SMN2 | |
| SCHEMBL691296 | 0.73 | PTK2 (0.56) | GAAPTK2MAPK1LMNA | |
| SCHEMBL691390 | 0.73 | PTK2 (0.46) | GAAPTK2MAPK1RPS6KA1LMNA | |
| SCHEMBL691573 | 0.73 | MAPK1 (0.50) | GAAPTK2MAPK1RPS6KA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |