Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 7/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691073 | 0.92 | GAA (0.46) | PTK2GAATSHRKDM4EGRM5 | |
| SCHEMBL691451 | 0.88 | MAPK1 (0.38) | PTK2GAATSHRNPC1LMNA | |
| SCHEMBL691927 | 0.86 | GAA (0.37) | PTK2GAATSHRNPC1LMNA | |
| SCHEMBL691468 | 0.82 | PTK2 (0.63) | PTK2GAATSHRKDM4EINSR | |
| SCHEMBL691296 | 0.82 | PTK2 (0.56) | PTK2GAALMNAALDH1A1HPGD | |
| SCHEMBL691659 | 0.80 | PTK2 (0.59) | PTK2 | |
| SCHEMBL690218 | 0.80 | PTK2 (0.58) | PTK2GAAINSRALDH1A1HPGD | |
| SCHEMBL692967 | 0.78 | PTK2 (0.73) | PTK2GAAALDH1A1 | |
| SCHEMBL689985 | 0.76 | PTK2 (0.45) | PTK2GAAKDM4ENPC1LMNA | |
| SCHEMBL691084 | 0.76 | PTK2 (0.47) | PTK2GAAKDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421537-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GlaxoSmithKline LLC (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010062578-A1 | PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK | GLAXOSMITHKLINE LLC (US) | 2010-06-03 | — | — | WO | disclosed |