SCHEMBL6919458

SCHEMBL6919458

CC(=O)Oc1ccc2c(C(=O)Nc3ccc(Cl)cc3-c3noc(=O)[nH]3)noc2c1.Cn1c(C(=O)Nc2ccc(Cl)cc2-c2noc(=O)[nH]2)cc2c(Br)cc(Br)c(NC(=O)Cc3ccccc3)c21

nearest known ligand 0.34

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
PKM P14618 1/20 0.34
GAA P10253 1/20 0.33
GRIK1 P39086 1/20 0.32
F11 P03951 1/20 0.32
HIF1A Q16665 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6709860 0.89 GRIK1 (0.39) KDM4EALDH1A1GAAGRIK1F11
SCHEMBL6711947 0.82 GRIK1 (0.35) KDM4EALDH1A1GAAGRIK1HIF1A
SCHEMBL6710187 0.81 F11 (0.40) KDM4EALDH1A1PKMGAAGRIK1
SCHEMBL6713562 0.81 HIF1A (0.41) KDM4EALDH1A1GAAGRIK1F11
SCHEMBL6710244 0.79 PARP14 (0.34) KDM4EALDH1A1GAAGRIK1
SCHEMBL6713299 0.76 HIF1A (0.43) GRIK1HIF1A
SCHEMBL6712257 0.76 ALDH1A1 (0.36) KDM4EALDH1A1PKMGAA
SCHEMBL6918234 0.75 HIF1A (0.35) ALDH1A1GRIK1HIF1A
SCHEMBL6711803 0.75 HIF1A (0.38) KDM4EALDH1A1GAAGRIK1HIF1A
SCHEMBL6707799 0.75 RORC (0.35) KDM4EGRIK1F11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018461-A2 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed