Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.51 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.41 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6825083 | 0.82 | GRIN2D (0.41) | MAPK14PADI4MEN1KMT2ACSF1R | |
| SCHEMBL6824577 | 0.80 | ALDH1A1 (0.47) | MEN1KMT2ACSF1RALDH1A1GSK3A | |
| SCHEMBL6825750 | 0.76 | PDE2A (0.58) | MAPK14MEN1KMT2ACSF1RPDE2A | |
| SCHEMBL1612248 | 0.74 | IMPDH2 (0.62) | CHUKMEN1KMT2ACSF1RALDH1A1 | |
| SCHEMBL3117686 | 0.72 | KDM4E (0.54) | MAPK14CHUKMEN1KMT2ACSF1R | |
| SCHEMBL6821955 | 0.70 | PADI4 (0.55) | MAPK14CHUKPADI4CSF1RALDH1A1 | |
| SCHEMBL17457312 | 0.70 | CSF1R (0.70) | MAPK14CSF1RCDK5GSK3AGSK3B | |
| SCHEMBL15648185 | 0.69 | KDM4E (0.70) | MEN1KMT2AALDH1A1TSHRCASP7 | |
| SCHEMBL9042203 | 0.69 | CHUK (0.59) | MAPK14CHUKPADI4MEN1KMT2A | |
| SCHEMBL21812474 | 0.68 | CHUK (0.50) | MAPK14CHUKCSF1RALDH1A1CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089930-A1 | 4-FLUOROQUINOLONE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS | IMCLONE SYSTEMS INCORPORATED (US) | 2004-10-21 | — | — | WO | disclosed |