Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.38 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.31 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6699862 | 0.91 | MMP13 (0.36) | MMP13SLC22A8PTGER4PTGER2SCD | |
| SCHEMBL6703290 | 0.89 | MMP13 (0.43) | MMP13SLC22A8PTGER4AGTR1AGTR2 | |
| SCHEMBL6694967 | 0.87 | MMP13 (0.46) | MMP13SLC22A8ALDH1A1HDAC6 | |
| SCHEMBL6699545 | 0.85 | MMP13 (0.39) | MMP13SLC22A8SCDSMN1; SMN2ALDH1A1 | |
| SCHEMBL6699931 | 0.80 | CLPP (0.38) | MMP13 | |
| SCHEMBL6701922 | 0.77 | SCD (0.36) | MMP13SLC22A8PTGER4PTGER2SCD | |
| SCHEMBL6289326 | 0.76 | MMP13 (0.43) | MMP13SLC22A8PTGER4SCDAGTR1 | |
| SCHEMBL6289360 | 0.74 | MMP13 (0.46) | MMP13SLC22A8ALDH1A1HDAC6 | |
| SCHEMBL6289349 | 0.74 | SCD (0.38) | MMP13SCDSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL6706890 | 0.70 | MMP13 (0.55) | MMP13SLC22A8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004014916-A1 | PYRIMIDINE FUSED BICYCLIC METALLOPROTEINASE INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-02-19 | — | — | WO | disclosed |