Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | NR2E1 | Q9Y466 | 4/20 | 0.38 |
| ▸ | CXCR3 | P49682 | 11/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11902113 | 0.77 | P2RX7 (0.44) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL11901828 | 0.71 | P2RY12 (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6920482 | 0.70 | P2RX7 (0.43) | P2RY12 | |
| Lithium Ion SCHEMBL1672091 | 0.69 | PDE4A (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL758948 | 0.68 | PSEN1 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL31142937 | 0.61 | SMN1; SMN2 (0.68) | CXCR3P2RY12 | |
| SCHEMBL31729819 | 0.61 | NR2E1 (0.81) | NR2E1 | |
| SCHEMBL24970972 | 0.60 | CXCR3 (0.63) | CXCR3P2RY12 | |
| SCHEMBL31142964 | 0.60 | CXCR3 (0.63) | CXCR3P2RY12 | |
| SCHEMBL19272800 | 0.60 | CYP1A2 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011048525-A1 | NOVEL HETEROARYL IMIDAZOLES AND HETEROARYL TRIAZOLES AS GAMMA-SECRETASE MODULATORS | PFIZER INC. (US) | 2011-04-28 | — | — | WO | disclosed |