Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.39 |
| ▸ | CTSD | P07339 | 7/20 | 0.34 |
| ▸ | BACE2 | Q9Y5Z0 | 7/20 | 0.34 |
| ▸ | REN | P00797 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL945865 | 0.88 | ALDH1A1 (0.35) | BACE1CTSDBACE2MEN1KMT2A | |
| SCHEMBL947083 | 0.87 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL944383 | 0.84 | — | — | |
| SCHEMBL944396 | 0.79 | NCOA1 (0.33) | ALDH1A1KDM4EGAA | |
| SCHEMBL932469 | 0.79 | BACE1 (0.31) | BACE1 | |
| SCHEMBL932503 | 0.74 | BACE1 (0.67) | BACE1CTSDBACE2REN | |
| SCHEMBL946379 | 0.71 | — | — | |
| SCHEMBL2282137 | 0.69 | BACE1 (0.51) | BACE1CTSDBACE2REN | |
| SCHEMBL2282142 | 0.69 | BACE1 (0.51) | BACE1CTSDBACE2REN | |
| SCHEMBL943316 | 0.69 | ALDH1A1 (0.34) | BACE1CTSDMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011002407-A1 | NOVEL COMPOUNDS FOR TREATMENT OF NEURODEGENERATION ASSOCIATED WITH DISEASES, SUCH AS ALZHEIMER'S DISEASE OR DEMENTIA | ASTRAZENECA AB (SE) | 2011-01-06 | — | — | WO | disclosed |