Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921979 | 0.90 | PRKDC (0.39) | RAB9ANPC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6920903 | 0.89 | ALDH1A1 (0.47) | RAB9ANPC1LMNAGRM2ALDH1A1 | |
| SCHEMBL12059543 | 0.87 | CYP3A4 (0.40) | RAB9ANPC1LMNAGRM2ALDH1A1 | |
| SCHEMBL6920542 | 0.85 | RAB9A (0.41) | RAB9ANPC1LMNAGRM2ALDH1A1 | |
| SCHEMBL6922253 | 0.80 | RAB9A (0.63) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6920833 | 0.80 | NPC1 (0.43) | RAB9ANPC1LMNAALDH1A1POLB | |
| SCHEMBL6921589 | 0.79 | NPC1 (0.42) | RAB9ANPC1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6923306 | 0.78 | RAB9A (0.43) | RAB9ANPC1LMNAGRM2ALDH1A1 | |
| SCHEMBL6921941 | 0.78 | GRM2 (0.40) | RAB9ANPC1LMNAGRM2ALDH1A1 | |
| SCHEMBL12059556 | 0.78 | RAB9A (0.43) | RAB9ANPC1LMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |