Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 9/20 | 0.43 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.41 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.39 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.39 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.39 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.39 |
| ▸ | PLA2G2F | Q9BZM2 | 1/20 | 0.39 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921144 | 0.86 | CYP19A1 (0.53) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6927241 | 0.84 | DRD2 (0.51) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6926400 | 0.83 | HTR1B (0.51) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6924418 | 0.83 | HTR1B (0.51) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6928709 | 0.83 | HTR1B (0.46) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6921216 | 0.81 | HTR1B (0.53) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6920002 | 0.81 | HRH1 (0.53) | CYP19A1 | |
| SCHEMBL6928704 | 0.80 | HTR1D (0.54) | CYP19A1P2RX4MCL1PLA2G2AUTS2R | |
| SCHEMBL6926928 | 0.80 | ESR1 (0.54) | HTR6 | |
| SCHEMBL6921654 | 0.80 | HTR6 (0.49) | CYP19A1UTS2RHTR6KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |