Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.53 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | DRD4 | P21917 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.53 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | LTA4H | P09960 | 5/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926928 | 0.99 | ESR1 (0.54) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL6926761 | 0.91 | HTR1A (0.53) | DRD1DRD3ESR1HTR1AHTR1D | |
| SCHEMBL6925328 | 0.90 | DRD1 (0.56) | DRD1DRD4DRD5ESR1TSHR | |
| SCHEMBL6927454 | 0.90 | LTA4H (0.49) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL6920834 | 0.90 | LMNA (0.52) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL6926720 | 0.88 | KDM4E (0.45) | DRD4ESR1DRD2HTR1AHTR1D | |
| SCHEMBL6924579 | 0.87 | ALDH1A1 (0.50) | DRD3DRD2HTR1AHTR1DHTR1B | |
| SCHEMBL6923678 | 0.85 | PLA2G2A (0.50) | DRD2HTR1AHTR1DHTR1BTDP1 | |
| SCHEMBL6923676 | 0.84 | HTR1A (0.45) | HRH1DRD1DRD4DRD5DRD3 | |
| SCHEMBL7505923 | 0.84 | ACHE (0.51) | HTR1AHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | claimed |
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |