Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 10/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921795 | 0.88 | GRM2 (0.46) | GRM2BCL2A1KCNH2 | |
| SCHEMBL6922513 | 0.87 | RXFP1 (0.45) | GRM2KCNH2HRH3 | |
| SCHEMBL6922768 | 0.86 | GRM5 (0.46) | GRM2ADORA2AADORA1 | |
| SCHEMBL6922377 | 0.84 | LMNA (0.41) | GRM2BCL2A1TGFBR1 | |
| SCHEMBL6922267 | 0.83 | GRM2 (0.48) | GRM2BCL2A1ADORA2AADORA1 | |
| SCHEMBL6923595 | 0.83 | GRM2 (0.41) | GRM2BCL2A1 | |
| SCHEMBL6923042 | 0.82 | RAB9A (0.39) | GRM2BCL2A1 | |
| SCHEMBL6923502 | 0.80 | BCL2A1 (0.37) | GRM2BCL2A1 | |
| SCHEMBL6922766 | 0.80 | ADORA2A (0.46) | GRM2ADORA2AADORA1 | |
| SCHEMBL12058968 | 0.79 | LMNA (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |