Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 6/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | CLPP | Q16740 | 1/20 | 0.44 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.44 |
| ▸ | BID | P55957 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059614 | 0.91 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2PKMUSP2HSD17B10 | |
| SCHEMBL6921007 | 0.85 | GRM2 (0.46) | GRM2ALDH1A1SMN1; SMN2PKMUSP2 | |
| SCHEMBL6921795 | 0.85 | GRM2 (0.46) | GRM2SMN1; SMN2BCL2A1 | |
| SCHEMBL6923595 | 0.84 | GRM2 (0.41) | GRM2ALDH1A1BCL2A1BID | |
| SCHEMBL6920958 | 0.83 | GRM2 (0.45) | GRM2ADORA2AADORA1BCL2A1 | |
| SCHEMBL6922513 | 0.82 | RXFP1 (0.45) | GRM2ALDH1A1SMN1; SMN2USP2HSD17B10 | |
| SCHEMBL6922377 | 0.81 | LMNA (0.41) | GRM2SMN1; SMN2LMNABCL2A1CYP2C19 | |
| SCHEMBL6921025 | 0.81 | ALDH1A1 (0.52) | GRM2ALDH1A1SMN1; SMN2PKMUSP2 | |
| SCHEMBL6923042 | 0.81 | RAB9A (0.39) | GRM2SMN1; SMN2HPGDLMNABCL2A1 | |
| SCHEMBL6923330 | 0.77 | KDM4E (0.58) | ALDH1A1SMN1; SMN2USP2HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |