Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 3/20 | 0.49 |
| ▸ | CA2 | P00918 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | CD74 | P04233 | 1/20 | 0.45 |
| ▸ | MIF | P14174 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HK1 | P19367 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923513 | 0.92 | HDAC1 (0.76) | HDAC1HDAC6PTGS1PTGS2CA1 | |
| SCHEMBL6925477 | 0.88 | PTGS1 (0.65) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 | |
| SCHEMBL14894319 | 0.87 | HDAC1 (0.79) | HDAC1HDAC6PTGS1PTGS2FABP4 | |
| SCHEMBL6925062 | 0.86 | PTGS1 (0.58) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 | |
| SCHEMBL30480036 | 0.85 | HDAC1 (0.70) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 | |
| SCHEMBL6925178 | 0.85 | HDAC1 (0.70) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 | |
| SCHEMBL7547764 | 0.84 | HDAC1 (0.69) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 | |
| SCHEMBL6926059 | 0.84 | PTGS1 (0.67) | HDAC1HDAC6PTGS1PTGS2CA1 | |
| SCHEMBL10155031 | 0.83 | BCHE (0.66) | HDAC1HDAC6BCHE | |
| SCHEMBL6919959 | 0.83 | HTR6 (0.59) | HDAC1HDAC6PTGS1PTGS2CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |