Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.51 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920011 | 0.91 | MAPK1 (0.54) | HTR6PTGS1PTGS2TSHRMAPK1 | |
| SCHEMBL6925062 | 0.85 | PTGS1 (0.58) | PTGS1PTGS2MAPK1KMT2AHDAC1 | |
| SCHEMBL6925477 | 0.83 | PTGS1 (0.65) | PTGS1PTGS2MAPK1HDAC1HDAC6 | |
| SCHEMBL6921299 | 0.83 | HDAC1 (0.69) | PTGS1PTGS2HDAC1HDAC6CSNK2A2 | |
| SCHEMBL30480036 | 0.81 | HDAC1 (0.70) | HTR6PTGS1PTGS2HDAC1HDAC6 | |
| SCHEMBL6925178 | 0.81 | HDAC1 (0.70) | HTR6PTGS1PTGS2HDAC1HDAC6 | |
| SCHEMBL7547764 | 0.80 | HDAC1 (0.69) | HTR6PTGS1PTGS2HDAC1HDAC6 | |
| SCHEMBL7547761 | 0.79 | HDAC1 (0.67) | HTR6PTGS1PTGS2HDAC1HDAC6 | |
| SCHEMBL9596229 | 0.78 | ALDH1A1 (0.50) | MAPK1KMT2A | |
| SCHEMBL6923513 | 0.76 | HDAC1 (0.76) | PTGS1PTGS2HDAC1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |