Sugi Predict

Sugi Predict / Compounds / SCHEMBL6921640

SCHEMBL6921640

SCHEMBL6921640

Fc1cc2occc2cc1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IDO1 P14902 5/20 0.43
▸ CYP2A6 P11509 3/20 0.40
▸ KDM4E B2RXH2 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40
▸ CYP2C9 P11712 1/20 0.40
▸ NFKB1 P19838 1/20 0.40
▸ MAOA P21397 1/20 0.40
▸ ACHE P22303 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ DYRK1A Q13627 3/20 0.35
▸ CTNNB1 P35222 1/20 0.35
▸ WNT3A P56704 1/20 0.35
▸ CDK9 P50750 1/20 0.34
▸ EPM2A O95278 1/20 0.34
▸ PTPRC P08575 1/20 0.34
▸ PTPN6 P29350 1/20 0.34
▸ CDC14A Q9UNH5 1/20 0.34
▸ PTPN22 Q9Y2R2 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24138808 0.92 IDO1 (0.43) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL14152298 0.85 IDO1 (0.41) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL8798702 0.82 CYP2A6 (0.45) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL2260966 0.82 CYP2A6 (0.45) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL10431458 0.80 CYP2A6 (0.44) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL3649528 0.77 CYP2A6 (0.41) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL18876066 0.75 CYP2A6 (0.40) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL16048196 0.75 IDO1 (0.44) IDO1CYP2A6KDM4ECYP3A4CYP2D6
SCHEMBL6819229 0.75 CYP2A6 (0.40) CYP2A6KDM4ECYP3A4CYP2D6CYP2C9
SCHEMBL2149910 0.74 CYP2A6 (0.54) CYP2A6KDM4ECYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11318133-B2 Modulators of integrated stress response pathway Praxis Biotech LLC (US) 2022-05-03 — — US disclosed
US-20210403482-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2021-12-30 — — US disclosed
US-11166942-B2 Inhibitors of integrated stress response pathway Praxis Biotech LLC (US) 2021-11-09 — — US disclosed
US-20210317102-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ALTOS LABS, INC. 2021-10-14 — — US disclosed
US-20200390759-A1 MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY Praxis Biotech LLC 2020-12-17 — — US disclosed
WO-2020252205-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY Praxis Biotech LLC (US) 2020-12-17 — — WO disclosed
US-20200101047-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY Praxis Biotech LLC 2020-04-02 — — US disclosed
US-10562897-B2 Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators JANSSEN PHARMACEUTICA NV (BE) 2020-02-18 — — US disclosed
US-10246454-B2 Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators JANSSEN PHARMACEUTICA NV (BE) 2019-04-02 — — US disclosed
EP-2993169-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS Novartis AG (CH) 2016-03-09 — — EP disclosed
EP-2501678-B1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2015-09-23 — — EP disclosed
US-8519134-B2 Aryl-pyridine derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-08-27 — — US disclosed
US-8519134-B2 Aryl-pyridine derivatives as aldosterone synthase inhibitors NOVARTIS AG (CH) 2013-08-27 — — US disclosed
US-20120316195-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-12-13 — — US disclosed
US-20120316195-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2012-12-13 — — US disclosed
WO-2011061168-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS NOVARTIS AG (CH) 2011-05-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10246454-B2 Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators BACE1, BACE2, PSEN1 IDO1 2794/4885CYP2A6 1119/4885KDM4E 1691/4885
US-20210317102-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, DDIT3, ATF1 IDO1 2040/4885CYP2A6 4003/4885KDM4E 4626/4885
US-11166942-B2 Inhibitors of integrated stress response pathway ATF4, DDIT3, ATF1 IDO1 2040/4885CYP2A6 4003/4885KDM4E 4626/4885
US-20120316195-A1 ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS CYP21A2, CYP11B1, CYP17A1 IDO1 799/4885CYP2A6 63/4885KDM4E 1096/4885
US-20200390759-A1 MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, ATF1, DDIT3 IDO1 2700/4885CYP2A6 4132/4885KDM4E 4591/4885
US-11318133-B2 Modulators of integrated stress response pathway ATF4, ATF1, DDIT3 IDO1 2700/4885CYP2A6 4132/4885KDM4E 4591/4885
US-20210403482-A1 TETRAZOLE DERIVATIVES AS TRPA1 INHIBITORS TRPA1, TRPV1, TRPV5 IDO1 2963/4885CYP2A6 3564/4885KDM4E 4765/4885
US-20200101047-A1 INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY ATF4, DDIT3, ATF1 IDO1 2040/4885CYP2A6 4003/4885KDM4E 4626/4885
US-10562897-B2 Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators BACE1, BACE2, PSEN1 IDO1 2794/4885CYP2A6 1119/4885KDM4E 1691/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.