Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23997651 | 0.94 | HTR2C (0.46) | HTR2CALDH1A1GID4HTR2BHTR2A | |
| SCHEMBL6923367 | 0.92 | HTR2C (0.50) | HTR2CALDH1A1GID4HTR2BHTR2A | |
| SCHEMBL23997637 | 0.92 | HTR2C (0.50) | HTR2CALDH1A1GID4HTR2BHTR2A | |
| SCHEMBL15298963 | 0.89 | ALDH1A1 (0.48) | HTR2CALDH1A1GID4HTR2BHTR2A | |
| SCHEMBL17231972 | 0.87 | ALDH1A1 (0.48) | HTR2CALDH1A1GID4IDO1F2 | |
| SCHEMBL6925738 | 0.87 | ALDH1A1 (0.48) | HTR2CALDH1A1GID4IDO1F2 | |
| SCHEMBL23997715 | 0.83 | GID4 (0.45) | HTR2CALDH1A1GID4HTR2BHTR2A | |
| SCHEMBL17231940 | 0.81 | HTR2C (0.58) | HTR2CGID4HTR2BHTR2AKDM4E | |
| SCHEMBL17231953 | 0.81 | HTR2C (0.58) | HTR2CGID4HTR2BHTR2AKDM4E | |
| SCHEMBL6925098 | 0.81 | HTR2C (0.46) | HTR2CALDH1A1GID4HTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515011-B2 | Anticoagulants | MERCK & CO., INC. | 2003-02-04 | — | — | US | disclosed |
| US-20020119992-A1 | Thrombin inhibitors | MERCK & CO., INC. | 2002-08-29 | — | — | US | disclosed |
| WO-2002050056-A1 | BENZYLAMINE DERIVATIVES AND THEIR USE AS THROMBIN INHIBITORS | MERCK & CO., INC. (US) | 2002-06-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020119992-A1 | Thrombin inhibitors | SERPINC1, F2, TFPI | HTR2C 524/4885ALDH1A1 4773/4885GID4 3422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.