Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27369615 | 0.74 | ALDH1A1 (0.35) | ALDH1A1TDP1 | |
| SCHEMBL8517093 | 0.73 | TXNRD1 (0.34) | ALDH1A1TDP1 | |
| SCHEMBL5367353 | 0.66 | ALDH1A1 (0.38) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL28258602 | 0.63 | CYP3A4 (0.59) | ALDH1A1CYP3A4HPGDTDP1 | |
| SCHEMBL7416771 | 0.63 | ALDH1A1 (0.36) | ALDH1A1 | |
| SCHEMBL3839311 | 0.62 | CYP3A4 (0.56) | ALDH1A1CYP3A4 | |
| SCHEMBL3843245 | 0.62 | TSHR (0.56) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL4038529 | 0.62 | TDP1 (0.52) | ALDH1A1CYP3A4TDP1 | |
| SCHEMBL31152344 | 0.62 | ALDH1A1 (0.51) | ALDH1A1CYP3A4HPGDTDP1 | |
| SCHEMBL3836840 | 0.62 | ALDH1A1 (0.51) | ALDH1A1CYP3A4HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194143-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1194143-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-10 | — | — | EP | disclosed |
| US-6262113-B1 | HYDROXY- OR MERCAPTO-PHENYLUREAS | SMITHKLINE BEECHAM CORPORATION | 2001-07-17 | — | — | US | disclosed |
| US-6211373-B1 | Phenyl urea antagonists of the IL-8 receptor | SMITHKLINE BEECHAM CORPORATION | 2001-04-03 | — | — | US | disclosed |
| WO-2000076457-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| US-6005008-A | IL-8 receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1999-12-21 | — | — | US | disclosed |