Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922350 | 1.00 | TP53 (0.34) | TP53GAAKDM4EGLAADRA2C | |
| SCHEMBL3257682 | 0.82 | — | — | |
| SCHEMBL11878881 | 0.80 | — | — | |
| SCHEMBL27696934 | 0.79 | GAA (0.36) | TP53GAAKDM4EGLAADRA2C | |
| SCHEMBL26303973 | 0.78 | CAPN1 (0.41) | TP53GAAADRA2CCAPN1ELANE | |
| SCHEMBL8991928 | 0.72 | ALDH1A1 (0.33) | TP53ELANE | |
| SCHEMBL20516454 | 0.69 | HDAC6 (0.53) | CAPN1 | |
| SCHEMBL20516455 | 0.69 | HDAC6 (0.53) | CAPN1 | |
| SCHEMBL9064406 | 0.68 | L3MBTL1 (0.30) | — | |
| SCHEMBL818514 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024060-A2 | METALLOPROTEINASE INHIBITORS AND INTERMEDIATES FOR PREPARATION THEREOF | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |