Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.34 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7154816 | 0.81 | SYK (0.35) | NOTUMSMN1; SMN2GRM5ALDH1A1MEN1 | |
| SCHEMBL6924757 | 0.74 | P4HTM (0.34) | GRM5 | |
| SCHEMBL22920208 | 0.71 | ALDH1A1 (0.45) | NOTUMSMN1; SMN2ALDH1A1KMT2AMAPK1 | |
| SCHEMBL15236764 | 0.71 | ALDH1A1 (0.45) | NOTUMSMN1; SMN2ALDH1A1KMT2AMAPK1 | |
| SCHEMBL9465064 | 0.71 | NOTUM (0.56) | NOTUMGRM5USP30MLLT3MLLT1 | |
| SCHEMBL28934722 | 0.70 | NOTUM (0.45) | NOTUMSMN1; SMN2ALDH1A1KMT2AMAPK1 | |
| SCHEMBL891991 | 0.70 | S1PR3 (0.55) | SMN1; SMN2HCRTR2HSD17B10NPC1RAB9A | |
| SCHEMBL28312083 | 0.70 | NOTUM (0.53) | NOTUM | |
| SCHEMBL28875500 | 0.69 | NOTUM (0.53) | NOTUM | |
| SCHEMBL892519 | 0.69 | HSD17B10 (0.53) | SMN1; SMN2HCRTR2HSD17B10NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004050624-A1 | SUBSTITUTED 1H-PYRIDINE-2-ONE DERIVATIVES | C & C RESEARCH LABORATORIES (KR) | 2004-06-17 | — | — | WO | disclosed |