Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | LPL | P06858 | 5/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8265696 | 0.89 | CA1 (0.43) | HSD11B1LPLLIPGHIF1ACA1 | |
| SCHEMBL1118822 | 0.86 | HSD11B1 (0.43) | HSD11B1LPLLIPGNPC1RAB9A | |
| SCHEMBL30542268 | 0.86 | DHFR (0.37) | HSD11B1LPLLIPGNPC1RAB9A | |
| SCHEMBL25217625 | 0.86 | DHFR (0.37) | HSD11B1LPLLIPGNPC1RAB9A | |
| SCHEMBL14184913 | 0.83 | HSD11B1 (0.37) | HSD11B1LPLLIPGNPC1RAB9A | |
| SCHEMBL14184918 | 0.82 | CA1 (0.39) | HSD11B1LPLLIPGHIF1ACA1 | |
| SCHEMBL17962846 | 0.81 | LPL (0.43) | LPLLIPGHIF1ACA1CA2 | |
| SCHEMBL21117326 | 0.81 | HIF1A (0.34) | HSD11B1LPLLIPGHIF1ACA1 | |
| SCHEMBL6067858 | 0.81 | HSD11B1 (0.40) | HSD11B1NPC1RAB9AHIF1ADHFR | |
| SCHEMBL17962779 | 0.80 | LPL (0.46) | LPLLIPGHIF1ACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004024060-A2 | METALLOPROTEINASE INHIBITORS AND INTERMEDIATES FOR PREPARATION THEREOF | ASTRAZENECA AB (SE) | 2004-03-25 | — | — | WO | disclosed |