Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099518 | 0.90 | CA12 (0.47) | HDAC8GAAMAPTL3MBTL1CA12 | |
| SCHEMBL5450436 | 0.80 | PTGS2 (0.53) | HDAC8GAAMAPTATMCYP2C19 | |
| SCHEMBL5450434 | 0.80 | PTGS2 (0.53) | HDAC8GAAMAPTATMCYP2C19 | |
| SCHEMBL9834835 | 0.79 | ATM (0.46) | GAAMAPTL3MBTL1CA12CA1 | |
| SCHEMBL7331705 | 0.79 | ATM (0.46) | GAAMAPTL3MBTL1CA12CA1 | |
| SCHEMBL10913291 | 0.78 | NPC1 (0.56) | HDAC8GAAMAPTL3MBTL1CTSL | |
| SCHEMBL6931994 | 0.78 | HDAC8 (0.53) | HDAC8GAAMAPTL3MBTL1CA12 | |
| SCHEMBL7962509 | 0.78 | HDAC8 (0.53) | HDAC8GAAMAPTL3MBTL1CA12 | |
| SCHEMBL10913288 | 0.78 | NPC1 (0.56) | HDAC8GAAMAPTL3MBTL1CTSL | |
| SCHEMBL7962506 | 0.78 | HDAC8 (0.53) | HDAC8GAAMAPTL3MBTL1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518435-B1 | Production method, a method of producing a compound represented by the formula (III) production method of oxyimino- alkanoic acid derivatives having an anti-diabetic activity. | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-02-11 | — | — | US | disclosed |
| EP-1227081-A1 | PROCESS FOR THE PREPARATION OF OXYIMINOALKANOIC ACID DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-07-31 | — | — | EP | disclosed |