Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7331705 | 1.00 | ATM (0.46) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL16513121 | 0.86 | ATM (0.46) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL11099518 | 0.84 | CA12 (0.47) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL6923110 | 0.79 | HDAC8 (0.46) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL2470468 | 0.78 | ATM (0.48) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL17533331 | 0.77 | KMT2A (0.54) | ATMCYP2C19LMNAALOX15MAPT | |
| SCHEMBL11725218 | 0.77 | GAA (0.51) | GAACA1CA2CA9LMNA | |
| SCHEMBL3891431 | 0.76 | GSK3B (0.48) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL22024926 | 0.76 | GSK3B (0.48) | ATMGAACYP2C19CA12CA1 | |
| SCHEMBL6161952 | 0.76 | GSK3B (0.48) | ATMGAACYP2C19CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0265169-B1 | OXADIAZINES & RELATED COMPOUNDS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-07-24 | — | — | EP | disclosed |
| US-4918188-A | Oxadiazines | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-04-17 | — | — | US | disclosed |
| US-4849516-A | PENICILLIN AND CEPHALOSPORIN ANTIBIOTIC INTERMEDIATES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-07-18 | — | — | US | disclosed |
| EP-0265169-A1 | Oxadiazines & related compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-04-27 | — | — | EP | disclosed |