Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929872 | 0.88 | KDM4E (0.53) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6926487 | 0.81 | ALDH1A1 (0.46) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6511595 | 0.79 | HPGD (0.39) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL18779471 | 0.79 | ALDH1A1 (0.72) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL20383970 | 0.79 | LMNA (0.50) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6926210 | 0.78 | ALDH1A1 (0.53) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6924085 | 0.77 | ERN1 (0.43) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6923230 | 0.77 | ERN1 (0.43) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL6927617 | 0.77 | MAPT (0.59) | LMNAHPGDL3MBTL1ALDH1A1MAPT | |
| SCHEMBL5459292 | 0.75 | HPGD (0.83) | LMNAHPGDL3MBTL1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |