Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ERN1 | O75460 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925044 | 0.81 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL6929872 | 0.78 | KDM4E (0.53) | ALDH1A1BLML3MBTL1MEN1KMT2A | |
| SCHEMBL6923162 | 0.78 | LMNA (0.47) | ALDH1A1BLML3MBTL1MEN1KMT2A | |
| SCHEMBL17345591 | 0.76 | HPGD (0.63) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL12871 | 0.75 | PHGDH (0.69) | ALDH1A1L3MBTL1KMT2AMAPTHPGD | |
| SCHEMBL13638958 | 0.72 | ERN1 (0.53) | ALDH1A1L3MBTL1KMT2AHPGDERN1 | |
| SCHEMBL17194215 | 0.72 | HPGD (0.63) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL6926487 | 0.71 | ALDH1A1 (0.46) | ALDH1A1BLML3MBTL1MEN1KMT2A | |
| SCHEMBL16302094 | 0.71 | HPGD (0.62) | ALDH1A1L3MBTL1MEN1KMT2AMAPT | |
| SCHEMBL31428978 | 0.71 | ALDH1A1 (0.58) | ALDH1A1KMT2AHPGDERN1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |