Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | MITF | O75030 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP14 | P54578 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | USP7 | Q93009 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP5 | P45974 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922486 | 0.89 | ALDH1A1 (0.45) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6922806 | 0.88 | SMN1; SMN2 (0.48) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6921657 | 0.86 | NOTUM (0.65) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6922796 | 0.86 | SMN1; SMN2 (0.46) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6923363 | 0.83 | ALDH1A1 (0.48) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6922931 | 0.83 | USP14 (0.49) | ALDH1A1HTTRAB9AMEN1KMT2A | |
| SCHEMBL6922881 | 0.82 | SMN1; SMN2 (0.46) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL17286129 | 0.82 | RAB9A (0.45) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL6923190 | 0.79 | USP14 (0.47) | ALDH1A1MITFMAPTHTTRAB9A | |
| SCHEMBL19749201 | 0.77 | NOTUM (0.56) | ALDH1A1MITFMAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011094545-A2 | COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-04 | — | — | WO | disclosed |