Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.54 |
| ▸ | HTT | P42858 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MITF | O75030 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30007326 | 0.78 | NOTUM (0.71) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL27172293 | 0.78 | NOTUM (0.71) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL6923422 | 0.76 | SMN1; SMN2 (0.65) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL28817946 | 0.75 | CHRNA7 (0.53) | ALDH1A1MAPTHTTRAB9AKMT2A | |
| SCHEMBL18362669 | 0.71 | ALDH1A1 (0.76) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL15919336 | 0.70 | ALDH1A1 (0.76) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL23524506 | 0.69 | NOTUM (0.59) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL18356164 | 0.69 | NOTUM (0.72) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL18355793 | 0.69 | NOTUM (0.69) | NOTUMALDH1A1MAPTHTTRAB9A | |
| SCHEMBL6922318 | 0.69 | RAB9A (0.67) | NOTUMALDH1A1MAPTHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011094545-A2 | COMPOSITIONS AND METHODS FOR ENHANCING PROTEASOME ACTIVITY | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-04 | — | — | WO | disclosed |