Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GFER | P55789 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | YWHAG | P61981 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL691717 | 0.86 | MDM2 (0.37) | SIGMAR1HTR2C | |
| SCHEMBL31543885 | 0.85 | NR1H2 (0.43) | SIGMAR1KDM4EMAPTTHRB | |
| SCHEMBL2017721 | 0.85 | NR1H2 (0.43) | SIGMAR1KDM4EMAPTTHRB | |
| SCHEMBL691094 | 0.83 | SIGMAR1 (0.43) | SIGMAR1KDM4EKMT2AGAAMEN1 | |
| SCHEMBL3723983 | 0.82 | LMNA (0.42) | KMT2AGAATDP1MEN1MAPT | |
| SCHEMBL3723985 | 0.82 | LMNA (0.42) | KMT2AGAATDP1MEN1MAPT | |
| SCHEMBL691883 | 0.81 | HTR2C (0.41) | SIGMAR1KDM4EKMT2AMEN1HTR2C | |
| SCHEMBL3630035 | 0.80 | BRD4 (0.39) | SIGMAR1KMT2AGAASMYD3 | |
| SCHEMBL3626167 | 0.80 | BRD4 (0.39) | SIGMAR1KMT2AGAASMYD3 | |
| SCHEMBL16819095 | 0.79 | TSHR (0.38) | SIGMAR1KMT2AMEN1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150607-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124042-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBOTT LABORATORIES (US) | 2010-10-28 | — | — | WO | disclosed |