SCHEMBL6923722

SCHEMBL6923722

O=C1NC(=S)SC1=Cc1cc(=O)[nH]c(SCc2ccc(Cl)c(Cl)c2)n1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NAT1 P18440 2/20 0.50
PTP4A3 O75365 1/20 0.47
CRHBP P24387 1/20 0.47
CRHR2 Q13324 1/20 0.47
ADAMTS5 Q9UNA0 2/20 0.45
DAO P14920 1/20 0.43
PIK3CG P48736 1/20 0.43
PIM1 P11309 6/20 0.43
MYC P01106 2/20 0.42
MAX P61244 2/20 0.42
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
ADAMTS4 O75173 1/20 0.41
LMNA P02545 2/20 0.41
MAPT P10636 2/20 0.41
SCN9A Q15858 1/20 0.41
DNM1 Q05193 1/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6927371 0.80 NAT1 (0.50) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL6923540 0.80 NAT1 (0.50) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL6923538 0.80 NAT1 (0.50) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL12892058 0.68 NAT1 (1.00) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL7962398 0.68 NAT1 (1.00) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL6781138 0.68 NAT1 (1.00) NAT1PTP4A3CRHBPCRHR2ADAMTS5
SCHEMBL6923134 0.67 NPSR1 (0.49) ADAMTS5PIM1NPC1RAB9ALMNA
SCHEMBL6923137 0.67 NPSR1 (0.49) ADAMTS5PIM1NPC1RAB9ALMNA
SCHEMBL7958249 0.67 MMP13 (0.70) NAT1ADAMTS5HPGD
SCHEMBL7958251 0.67 MMP13 (0.70) NAT1ADAMTS5HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6518268-B1 Telomerase inhibitors and methods of their use GERON CORPORATION 2003-02-11 US claimed
WO-2001002377-A9 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORP (US) 2001-10-11 WO claimed
EP-1109796-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE Geron Corporation (US) 2001-06-27 EP claimed
WO-2001002377-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORPORATION (US) 2001-01-11 WO claimed
US-6518268-B1 Telomerase inhibitors and methods of their use GERON CORPORATION 2003-02-11 US disclosed
WO-2001002377-A9 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORP (US) 2001-10-11 WO disclosed
EP-1109796-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE Geron Corporation (US) 2001-06-27 EP disclosed
WO-2001002377-A1 TELOMERASE INHIBITORS AND METHODS OF THEIR USE GERON CORPORATION (US) 2001-01-11 WO disclosed