Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | PKLR | P30613 | 1/20 | 0.49 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6828029 | 0.88 | ALDH1A1 (0.54) | ALDH1A1PKMHSD17B1HSD17B2GAA | |
| SCHEMBL3071479 | 0.86 | ALDH1A1 (0.52) | ALDH1A1PKMHSD17B1HSD17B2GAA | |
| SCHEMBL27422860 | 0.86 | ALDH1A1 (0.67) | ALDH1A1HSD17B1HSD17B2GAALMNA | |
| SCHEMBL3061841 | 0.85 | LMNA (0.53) | ALDH1A1PKMHSD17B1HSD17B2GAA | |
| SCHEMBL27421591 | 0.84 | HSD17B1 (0.53) | ALDH1A1PKMHSD17B1HSD17B2GAA | |
| SCHEMBL27422413 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HSD17B1HSD17B2GAALMNA | |
| SCHEMBL27421458 | 0.83 | KMT2A (0.62) | ALDH1A1HSD17B1HSD17B2GAALMNA | |
| SCHEMBL6926084 | 0.82 | POLB (0.56) | ALDH1A1PKMPKLRLMNATDP1 | |
| SCHEMBL27421447 | 0.80 | HSD17B1 (0.57) | ALDH1A1HSD17B1HSD17B2GAALMNA | |
| SCHEMBL3053691 | 0.78 | LMNA (0.54) | ALDH1A1PKMPKLRLMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004073619-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | claimed |
| WO-2004073619-A2 | CCR8 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-09-02 | — | — | WO | disclosed |