Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD1 | Q15139 | 13/20 | 0.65 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924065 | 0.95 | PRKD1 (0.64) | PRKD1RETKDRHRH3ADORA3 | |
| SCHEMBL1079502 | 0.90 | PRKD1 (0.70) | PRKD1NPC1TP53GAAMAPT | |
| SCHEMBL1053391 | 0.86 | PRKD1 (0.70) | PRKD1NPC1TP53GAAMAPT | |
| SCHEMBL960488 | 0.86 | PRKD1 (0.70) | PRKD1NPC1TP53GAAMAPT | |
| SCHEMBL6924052 | 0.86 | PRKD1 (0.69) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL962069 | 0.84 | PRKD1 (0.66) | PRKD1RETKDR | |
| SCHEMBL937410 | 0.84 | PRKD1 (0.81) | PRKD1ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL6923756 | 0.83 | PRKD1 (0.66) | PRKD1NPC1TP53GAAMAPT | |
| SCHEMBL1024920 | 0.82 | PRKD1 (0.64) | PRKD1NPC1TP53GAAMAPT | |
| SCHEMBL936452 | 0.81 | PRKD1 (0.74) | PRKD1ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011009484-A1 | ARYLPYRAZOLES AND ARYLISOXAZOLES AND THEIR USE AS PKD MODULATORS | NOVARTIS AG (CH) | 2011-01-27 | — | — | WO | disclosed |