Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 5/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.39 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.39 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7465826 | 0.91 | SMN1; SMN2 (0.58) | SMN1; SMN2MAPK1KMT2ALMNARAB9A | |
| SCHEMBL7464550 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK1KMT2ALMNARAB9A | |
| SCHEMBL7472132 | 0.83 | CTSL (0.39) | SMN1; SMN2MAPK1KMT2ALMNARAB9A | |
| SCHEMBL7463889 | 0.82 | CTSL (0.49) | CTSLCTSBCTSSCTSKPSMB5 | |
| SCHEMBL6927425 | 0.81 | CTSL (0.55) | CTSLCTSBCTSSCTSK | |
| SCHEMBL7464820 | 0.81 | CTSL (0.47) | SMN1; SMN2ALDH1A1KDM4ECTSLCTSB | |
| SCHEMBL7467469 | 0.80 | CTSL (0.47) | CTSLCTSBCTSSCTSK | |
| SCHEMBL7468905 | 0.80 | CTSK (0.53) | CTSLCTSBCTSSCTSK | |
| SCHEMBL7467318 | 0.79 | CTSL (0.53) | CTSLCTSBCTSSCTSK | |
| SCHEMBL7473272 | 0.79 | CTSL (0.48) | KMT2ACTSLCTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | claimed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |