Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.49 |
| ▸ | PLA2G2A | P14555 | 15/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921601 | 0.91 | PLA2G2A (0.47) | HTR6PLA2G2AALDH1A1POLBHTT | |
| SCHEMBL6921602 | 0.88 | ABCG2 (0.48) | PLA2G2AKMT2AALDH1A1POLBNTRK1 | |
| SCHEMBL6923328 | 0.87 | PLA2G2A (0.45) | HTR6PLA2G2ATSHRKMT2APLA2G1B | |
| SCHEMBL6921144 | 0.85 | CYP19A1 (0.53) | HTR6PLA2G2APLA2G1BALDH1A1 | |
| SCHEMBL6924311 | 0.84 | P2RX4 (0.43) | HTR6PLA2G2AKMT2APOLBNTRK1 | |
| SCHEMBL6924426 | 0.84 | TSHR (0.47) | HTR6PLA2G2ATSHRMAPK1KMT2A | |
| SCHEMBL6920467 | 0.79 | PLA2G2A (0.55) | HTR6PLA2G2ATSHRMAPK1KMT2A | |
| SCHEMBL7517440 | 0.79 | TSHR (0.56) | HTR6PLA2G2ATSHRMAPK1KMT2A | |
| SCHEMBL6925585 | 0.79 | MEN1 (0.47) | HTR6PLA2G2ATSHRMAPK1KMT2A | |
| SCHEMBL6924330 | 0.78 | P2RX4 (0.52) | HTR6PLA2G2ATSHRPLA2G1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | claimed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | claimed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | claimed |
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |