Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 11/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919685 | 0.92 | PLA2G2A (0.44) | TSHRMAPK1KMT2APLA2G2ANTRK1 | |
| SCHEMBL6923666 | 0.87 | KMT2A (0.44) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6924402 | 0.84 | HTR6 (0.49) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL7517440 | 0.78 | TSHR (0.56) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6920467 | 0.78 | PLA2G2A (0.55) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6921601 | 0.75 | PLA2G2A (0.47) | PLA2G2ANTRK1HTR6MAPTP2RX4 | |
| SCHEMBL6921062 | 0.75 | MAPT (0.39) | TSHRKMT2APLA2G2APLA2G1BMAPT | |
| SCHEMBL6983559 | 0.74 | PLA2G2A (0.59) | PLA2G2APLA2G1B | |
| SCHEMBL818659 | 0.73 | PLA2G2A (0.43) | PLA2G2APLA2G1BMAPTSMN1; SMN2 | |
| SCHEMBL14280388 | 0.72 | P2RX4 (0.77) | TSHRMAPK1KMT2APLA2G2APLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |