Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 12/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920467 | 0.85 | PLA2G2A (0.55) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6983559 | 0.82 | PLA2G2A (0.59) | PLA2G2APLA2G1B | |
| SCHEMBL14280388 | 0.81 | P2RX4 (0.77) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6924402 | 0.79 | HTR6 (0.49) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6924426 | 0.78 | TSHR (0.47) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL6925937 | 0.75 | PLA2G2A (0.53) | PLA2G2APLA2G1BP2RX4NTRK1 | |
| SCHEMBL12301941 | 0.74 | KMT2A (0.68) | TSHRMAPK1KMT2APLA2G2APLA2G1B | |
| SCHEMBL29093447 | 0.74 | KMT2A (0.62) | KMT2AP2RX4 | |
| SCHEMBL30616062 | 0.74 | KMT2A (0.62) | KMT2AP2RX4 | |
| SCHEMBL8235994 | 0.73 | PLA2G2A (0.67) | TSHRMAPK1KMT2APLA2G2APLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |