Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ANPEP | P15144 | 2/20 | 0.45 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924631 | 1.00 | ANPEP (0.45) | ANPEPDPP4HSD11B1ALDH1A1CYP1A2 | |
| SCHEMBL6921473 | 1.00 | ANPEP (0.45) | ANPEPDPP4HSD11B1ALDH1A1CYP1A2 | |
| SCHEMBL6923507 | 0.81 | POLB (0.49) | DPP4HSD11B1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL6923510 | 0.81 | POLB (0.49) | DPP4HSD11B1ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL23417537 | 0.79 | HSD11B1 (0.41) | HSD11B1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL13878064 | 0.79 | HSD11B1 (0.41) | HSD11B1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL23417534 | 0.79 | HSD11B1 (0.41) | HSD11B1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL719504 | 0.76 | HSD11B1 (0.47) | HSD11B1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6919908 | 0.74 | ALDH1A1 (0.44) | ANPEPDPP4ALDH1A1 | |
| SCHEMBL6919906 | 0.74 | ALDH1A1 (0.44) | ANPEPDPP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |