Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 8/20 | 0.48 |
| ▸ | PLG | P00747 | 6/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.39 |
| ▸ | PLAT | P00750 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377689 | 0.88 | ACE (0.47) | F2OPRM1OPRK1FKBP1AACE | |
| SCHEMBL21068023 | 0.86 | OPRM1 (0.44) | F2OPRM1OPRK1FKBP1AACE | |
| Acetic Acid SCHEMBL10728075 | 0.85 | F2 (0.56) | F2PLGOPRM1OPRK1 | |
| SCHEMBL8950750 | 0.85 | ACE (0.43) | F2OPRM1OPRK1ACEEPHA2 | |
| SCHEMBL7356254 | 0.84 | F2 (0.57) | F2PLGF10PRSS1OPRM1 | |
| SCHEMBL6850981 | 0.84 | F2 (0.57) | F2PLGF10PRSS1OPRM1 | |
| SCHEMBL7356276 | 0.84 | F2 (0.57) | F2PLGF10PRSS1OPRM1 | |
| SCHEMBL6850997 | 0.84 | F2 (0.57) | F2PLGF10PRSS1OPRM1 | |
| SCHEMBL27532662 | 0.84 | F2 (0.57) | F2PLGF10PRSS1OPRM1 | |
| SCHEMBL27533421 | 0.84 | PLG (0.44) | F2PLGF10PRSS1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946178-A4 | COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE | MERCK & CO INC (US) | 2003-05-07 | — | — | EP | claimed |
| EP-0946178-A1 | COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE | Merck & Co., Inc. (US) | 1999-10-06 | — | — | EP | claimed |
| WO-1998011896-A1 | COMBINATION THERAPY FOR REDUCING THE RISKS ASSOCIATED WITH CARDIOVASCULAR DISEASE | MERCK & CO., INC. (US) | 1998-03-26 | — | — | WO | claimed |