Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 10/20 | 0.71 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.71 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.71 |
| ▸ | SGK1 | O00141 | 3/20 | 0.52 |
| ▸ | JAK2 | O60674 | 5/20 | 0.50 |
| ▸ | JAK1 | P23458 | 3/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24244917 | 0.83 | SGK1 (0.52) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL24244934 | 0.82 | MAPK8 (0.50) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| Hydrochloric Acid SCHEMBL6370463 | 0.82 | MAPK10 (0.97) | MAPK10MAPK14MAPK8KDM4EGAA | |
| SCHEMBL30338305 | 0.80 | MAPK10 (0.69) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL22562972 | 0.80 | MAPK10 (0.47) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL7073847 | 0.79 | MAPK10 (0.62) | MAPK10MAPK14MAPK8 | |
| SCHEMBL24244908 | 0.79 | SGK1 (0.47) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL22564684 | 0.79 | MAPK1 (0.47) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL24244979 | 0.77 | TRPA1 (0.55) | MAPK10MAPK14MAPK8SGK1JAK2 | |
| SCHEMBL6930752 | 0.76 | MAPK8 (0.58) | MAPK10MAPK14MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| US-20220041559-A1 | BENZO-AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | ROTTAPHARM BIOTECH S.R.L. (IT) | 2022-02-10 | — | — | US | disclosed |
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041559-A1 | BENZO-AND PYRIDO-PYRAZOLES AS PROTEIN KINASE INHIBITORS | PDXK, MAP4K2, PLK2 | MAPK10 201/4885MAPK14 90/4885MAPK8 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.