Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928888 | 0.79 | GSK3A (0.64) | MAPK8MAPK10MAPK14 | |
| SCHEMBL6931060 | 0.78 | MAPK8 (0.55) | MAPK8MAPK10MAPK14SOS1MAPK1 | |
| SCHEMBL7073847 | 0.77 | MAPK10 (0.62) | MAPK8MAPK10MAPK14MAPK1TRPA1 | |
| SCHEMBL6925012 | 0.76 | MAPK10 (0.71) | MAPK8MAPK10MAPK14 | |
| SCHEMBL7134630 | 0.75 | ULK1 (0.58) | MAPK8MAPK10MAPK14MAPK1 | |
| SCHEMBL6928950 | 0.74 | ULK1 (0.51) | MAPK8MAPK10MAPK14MAPK1 | |
| SCHEMBL1461079 | 0.74 | GSK3B (0.56) | ACHEMAPK1CDC7CRHR1 | |
| SCHEMBL6930259 | 0.73 | ULK1 (0.53) | MAPK8MAPK10MAPK14 | |
| Hydrochloric Acid SCHEMBL6370463 | 0.72 | MAPK10 (0.97) | MAPK8MAPK10MAPK14 | |
| SCHEMBL2129920 | 0.72 | EBP (0.57) | ACHECRHR1KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |