Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MC4R | P32245 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925072 | 1.00 | ALDH1A1 (0.49) | ALDH1A1HTTMAPTPKMHPGD | |
| SCHEMBL6789647 | 0.85 | TDP1 (0.42) | ALDH1A1HTTMAPTALOX15TDP1 | |
| Hydrochloric Acid SCHEMBL27657147 | 0.81 | HTR2B (0.40) | ALDH1A1HTTTDP1LMNACASP3 | |
| SCHEMBL28504657 | 0.79 | CYP1B1 (0.59) | ALDH1A1MAPTL3MBTL1LMNAKMT2A | |
| SCHEMBL28507217 | 0.79 | CYP1B1 (0.59) | ALDH1A1MAPTL3MBTL1LMNAKMT2A | |
| SCHEMBL6881201 | 0.79 | HTR3E (0.42) | ALDH1A1HTTMAPTTDP1TSHR | |
| SCHEMBL14928513 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HTTMAPTPKMHPGD | |
| SCHEMBL5139365 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HTTMAPTPKMHPGD | |
| SCHEMBL5601974 | 0.76 | TDP1 (0.51) | ALDH1A1HTTMAPTPKMHPGD | |
| SCHEMBL5600097 | 0.76 | TDP1 (0.51) | ALDH1A1HTTMAPTPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |