Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.70 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6924018 | 0.89 | MAPK8 (0.56) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| SCHEMBL6928890 | 0.83 | MAPK8 (0.55) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| Hydrochloric Acid SCHEMBL6370063 | 0.82 | MAPK10 (0.98) | MAPK8MAPK10MAPK14AAK1 | |
| SCHEMBL6929720 | 0.80 | MAPK8 (0.53) | MAPK8MAPK10MAPK14HDAC6 | |
| SCHEMBL6928888 | 0.79 | GSK3A (0.64) | MAPK8MAPK10MAPK14AAK1 | |
| Hydrochloric Acid SCHEMBL6370416 | 0.77 | MAPK10 (0.98) | MAPK8MAPK10MAPK14 | |
| SCHEMBL29568296 | 0.77 | FLT3 (0.56) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| SCHEMBL22551182 | 0.77 | FLT3 (0.56) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| SCHEMBL31561383 | 0.76 | FGFR1 (0.60) | MAPK10MAPK14HDAC6FGFR1FGFR2 | |
| SCHEMBL7134630 | 0.75 | ULK1 (0.58) | MAPK8MAPK10MAPK14AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |