Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 8/20 | 0.53 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928890 | 0.83 | MAPK8 (0.55) | MAPK8MAPK10MAPK14HDAC6GSK3A | |
| SCHEMBL1461477 | 0.82 | GSK3B (0.56) | MAPK1RAB9ANPC1CASP3SENP8 | |
| SCHEMBL6925889 | 0.80 | MAPK8 (0.70) | MAPK8MAPK10MAPK14HDAC6 | |
| SCHEMBL6928888 | 0.79 | GSK3A (0.64) | MAPK8MAPK10MAPK14CDK2GSK3A | |
| SCHEMBL17039074 | 0.78 | MAPK1 (0.53) | MAPK1RAB9ANPC1KMT2AMAPT | |
| SCHEMBL6924018 | 0.78 | MAPK8 (0.56) | MAPK8MAPK10MAPK14HDAC6 | |
| SCHEMBL4494227 | 0.78 | HDAC6 (0.65) | MAPK1HDAC6CDK2GSK3A | |
| SCHEMBL6931060 | 0.78 | MAPK8 (0.55) | MAPK8MAPK10MAPK14MAPK1KMT2A | |
| SCHEMBL7134630 | 0.77 | ULK1 (0.58) | MAPK8MAPK10MAPK14MAPK1CDK2 | |
| SCHEMBL4495224 | 0.76 | HDAC6 (0.67) | KMT2AHDAC6ALDH1A1MEN1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |