Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6925889 | 0.83 | MAPK8 (0.70) | MAPK8MAPK10MAPK14HDAC6JAK2 | |
| SCHEMBL6929720 | 0.83 | MAPK8 (0.53) | MAPK8MAPK10MAPK14HDAC6GSK3A | |
| SCHEMBL6924018 | 0.81 | MAPK8 (0.56) | MAPK8MAPK10MAPK14HDAC6JAK2 | |
| SCHEMBL6928888 | 0.79 | GSK3A (0.64) | MAPK8MAPK10MAPK14GSK3BGSK3A | |
| SCHEMBL17028029 | 0.78 | FGFR1 (0.48) | MAPK8MAPK10HDAC6GSK3BGSK3A | |
| SCHEMBL30495324 | 0.78 | FGFR1 (0.48) | MAPK8MAPK10HDAC6GSK3BGSK3A | |
| SCHEMBL7134630 | 0.77 | ULK1 (0.58) | MAPK8MAPK10MAPK14GSK3BGSK3A | |
| SCHEMBL22551182 | 0.76 | FLT3 (0.56) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| SCHEMBL29568296 | 0.76 | FLT3 (0.56) | MAPK8MAPK10MAPK14HDAC6FGFR1 | |
| SCHEMBL6928950 | 0.75 | ULK1 (0.51) | MAPK8MAPK10MAPK14GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | claimed |
| WO-2004113303-A1 | INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |