Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 | P30926 | 4/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070253 | 0.94 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ACA2 | |
| SCHEMBL16715355 | 0.86 | CHRNB4 (0.54) | CHRNB4CHRNA3MEN1KMT2ANPC1 | |
| SCHEMBL5846431 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ACA2 | |
| SCHEMBL1011265 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ANPC1 | |
| SCHEMBL1011267 | 0.86 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ANPC1 | |
| SCHEMBL5582594 | 0.82 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ACA2 | |
| SCHEMBL5937030 | 0.82 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ANPC1 | |
| SCHEMBL28607236 | 0.82 | CHRNB4 (0.48) | CHRNB4CHRNA3MEN1KMT2ACA2 | |
| SCHEMBL5582817 | 0.80 | ADRA2A (0.58) | CHRNB4CHRNA3MEN1KMT2AALDH1A1 | |
| SCHEMBL3033668 | 0.80 | CHRNB4 (0.51) | CHRNB4CHRNA3MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001766-B1 | COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES | SMITHKLINE BEECHAM CORP (US) | 2003-04-09 | — | — | EP | disclosed |
| US-6515027-B1 | Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 | SMITHKLINE BEECHAM CORP. | 2003-02-04 | — | — | US | disclosed |
| EP-1001766-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2001-04-04 | — | — | EP | disclosed |
| CN-1261795-A | Compounds and methods | SMITHKLINE BEECHAM CORP (US) | 2000-08-02 | — | — | CN | disclosed |
| EP-1001766-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-05-24 | — | — | EP | disclosed |
| WO-1999001127-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-01-14 | — | — | WO | disclosed |