Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | MERTK | Q12866 | 3/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | HCK | P08631 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926274 | 0.79 | PIK3CD (0.52) | PIK3CDPIK3CBPIK3CGPRKDCEGFR | |
| SCHEMBL30080758 | 0.69 | KDM4E (0.43) | XDHPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL26027589 | 0.66 | XDH (0.74) | XDHSRCABL1 | |
| SCHEMBL23630539 | 0.65 | ADK (0.39) | PIK3CDPIK3CBPIK3CGYTHDC1EGFR | |
| SCHEMBL15788906 | 0.64 | KMT2A (0.44) | XDHPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL6929476 | 0.64 | PIK3CD (0.48) | PIK3CDPIK3CBPIK3CGPRKDCEGFR | |
| SCHEMBL17818402 | 0.64 | ADK (0.45) | PIK3CDPIK3CBPIK3CGYTHDC1PRKDC | |
| SCHEMBL16864520 | 0.63 | PIK3CD (0.54) | PIK3CDPIK3CBPIK3CGPRKDCEGFR | |
| SCHEMBL462054 | 0.63 | PIK3CD (0.39) | XDHPIK3CDPIK3CBPIK3CGPRKDC | |
| SCHEMBL16604729 | 0.63 | ALDH1A1 (0.34) | PIK3CDPIK3CBPIK3CGYTHDC1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2549868-B1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2015-01-07 | — | — | EP | disclosed |