Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.52 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.52 |
| ▸ | ERN1 | O75460 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.41 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926312 | 1.00 | ALDH1A1 (0.56) | ALDH1A1LMNAPTGESGSTP1GSTM2 | |
| SCHEMBL6926310 | 0.85 | PTGES (0.56) | ALDH1A1LMNAPTGESGSTP1GSTM2 | |
| SCHEMBL6927792 | 0.81 | ERN1 (0.56) | ALDH1A1PTGESERN1GAAPDE7A | |
| SCHEMBL6929722 | 0.81 | GAA (0.55) | ALDH1A1LMNAPTGESERN1GAA | |
| SCHEMBL6929731 | 0.81 | GAA (0.69) | ALDH1A1LMNAPTGESERN1GAA | |
| SCHEMBL6922508 | 0.78 | PDE7A (0.55) | PTGESERN1GAAL3MBTL1PDE7A | |
| SCHEMBL6927608 | 0.78 | GAA (0.52) | ALDH1A1LMNAPTGESERN1GAA | |
| SCHEMBL4748682 | 0.78 | PDE7A (0.64) | ALDH1A1PTGESGSTP1GSTM2ERN1 | |
| SCHEMBL6926325 | 0.78 | GAA (0.58) | ALDH1A1LMNAPTGESERN1GAA | |
| SCHEMBL6929282 | 0.78 | GAA (0.52) | ALDH1A1PTGESERN1GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |