Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 3/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919906 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP2D6ANPEPDPP4 | |
| SCHEMBL6919908 | 1.00 | ALDH1A1 (0.44) | ALDH1A1HPGDCYP2D6ANPEPDPP4 | |
| SCHEMBL607042 | 0.77 | LMNA (0.58) | ALDH1A1HPGDCYP2D6CSNK2BCSNK2A1 | |
| SCHEMBL29393294 | 0.77 | LMNA (0.58) | ALDH1A1HPGDCYP2D6CSNK2BCSNK2A1 | |
| SCHEMBL6925572 | 0.77 | LMNA (0.58) | ALDH1A1HPGDCYP2D6CSNK2BCSNK2A1 | |
| SCHEMBL6101023 | 0.76 | ALDH1A1 (0.42) | ALDH1A1HPGDCYP2D6FAAHMAPT | |
| SCHEMBL7557936 | 0.76 | ALDH1A1 (0.47) | ALDH1A1HPGDCYP2D6FAAHMAPT | |
| SCHEMBL6921473 | 0.74 | ANPEP (0.45) | ALDH1A1ANPEPDPP4 | |
| SCHEMBL6924635 | 0.74 | ANPEP (0.45) | ALDH1A1ANPEPDPP4 | |
| SCHEMBL6924631 | 0.74 | ANPEP (0.45) | ALDH1A1ANPEPDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515129-B1 | A pharmaceutical composition which comprises, a cyclic imide derivative represented by the general formula (I): present invention relates to an aminopeptidase N inhibitor or an angiogenesis inhibitor, modulates production of tumor necrosis | ISHIHARA SANGYO KAISHA LTD. (JP) | 2003-02-04 | — | — | US | disclosed |
| US-6429212-B1 | AMINOPEPTIDASE N INHIBITOR USED TO TREAT CANCER, TUMORS, AND RETINOPATHY; FEW SIDE EFFECTS; ANGIOGENESIS INHIBITOR | ISHIHARA SANGYO KAISHA LTD. (JP) | 2002-08-06 | — | — | US | disclosed |