Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 3/20 | 0.40 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6919987 | 0.81 | CYP19A1 (0.49) | CYP19A1P2RX4CCR2UTS2RALDH1A1 | |
| Acetonitrile SCHEMBL27465807 | 0.75 | CYP19A1 (0.50) | CYP19A1P2RX4CCR2UTS2RALDH1A1 | |
| SCHEMBL27482466 | 0.73 | CYP19A1 (0.59) | CYP19A1P2RX4CCR2UTS2RALDH1A1 | |
| SCHEMBL6925221 | 0.73 | CYP19A1 (0.59) | CYP19A1P2RX4CCR2UTS2RALDH1A1 | |
| SCHEMBL6923666 | 0.72 | KMT2A (0.44) | CYP19A1P2RX4ALDH1A1MAPTTSHR | |
| SCHEMBL6921062 | 0.71 | MAPT (0.39) | CYP19A1P2RX4ALDH1A1MAPTTSHR | |
| SCHEMBL6924426 | 0.71 | TSHR (0.47) | P2RX4MAPTTSHRSMN1; SMN2KMT2A | |
| SCHEMBL8920050 | 0.69 | CYP19A1 (0.61) | CYP19A1P2RX4UTS2RALDH1A1KDM4E | |
| SCHEMBL17439171 | 0.69 | CYP19A1 (0.70) | CYP19A1P2RX4ALDH1A1KDM4EMAPT | |
| SCHEMBL30234033 | 0.69 | CYP19A1 (0.70) | CYP19A1P2RX4ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |