Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 10/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 3/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 3/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PLA2G2F | Q9BZM2 | 2/20 | 0.37 |
| ▸ | PLA2G2D | Q9UNK4 | 2/20 | 0.37 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.37 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.37 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.37 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.37 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921541 | 0.84 | HTR6 (0.47) | MAPTTP53PLA2G2APLA2G10PLA2G2E | |
| SCHEMBL6924339 | 0.78 | DRD2 (0.46) | MAPTTP53PLA2G2APLA2G10PLA2G2E | |
| SCHEMBL6923666 | 0.76 | KMT2A (0.44) | MAPTPLA2G2APLA2G10PLA2G2EPLA2G1B | |
| SCHEMBL6924122 | 0.75 | PLA2G2A (0.46) | MAPTTP53PLA2G2ACYP19A1HTT | |
| SCHEMBL6919685 | 0.75 | PLA2G2A (0.44) | MAPTTP53PLA2G2APLA2G10HTT | |
| SCHEMBL6924426 | 0.75 | TSHR (0.47) | MAPTPLA2G2APLA2G1BTSHRKMT2A | |
| SCHEMBL6921487 | 0.72 | ESR1 (0.43) | MAPTTP53PLA2G2AHTTLMNA | |
| SCHEMBL6926504 | 0.71 | CYP19A1 (0.48) | MAPTTP53CYP19A1LMNATSHR | |
| SCHEMBL6921052 | 0.69 | MEN1 (0.43) | MAPTTP53PLA2G2AHTTLMNA | |
| SCHEMBL6921144 | 0.69 | CYP19A1 (0.53) | PLA2G2APLA2G10PLA2G2EPLA2G1BPLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6514968-B1 | Treating a disease or condition in a mammal wherein the 5-HT receptor is implicated and modulation of 5-HT function is desired comprising | PHARMACIA & UPJOHN COMPANY | 2003-02-04 | — | — | US | disclosed |
| EP-1210329-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001017963-A2 | AMINOALKOXY CARBAZOLES AND THEIR USE AS 5-HT LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 2001-03-15 | — | — | WO | disclosed |