SCHEMBL6926699

SCHEMBL6926699

COc1ccc([N+](=O)[O-])cc1CCCN(C(C)C)C(C)C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
ALDH1A1 P00352 7/20 0.47
HTT P42858 3/20 0.47
HPGD P15428 3/20 0.47
KMT2A Q03164 2/20 0.47
APOBEC3A P31941 1/20 0.47
APOBEC3G Q9HC16 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
CYP19A1 P11511 1/20 0.43
LCK P06239 1/20 0.43
MAPT P10636 2/20 0.43
NPC1 O15118 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
RAB9A P51151 1/20 0.43
POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4361623 0.80 TDP1 (0.53) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL4200907 0.78 SMN1; SMN2 (0.52) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL8973826 0.78 TDP1 (0.57) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL6924928 0.78 ALDH1A1 (0.49) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL6604502 0.77 ADRA1A (0.43) HTTCYP19A1MAPT
SCHEMBL29560265 0.76 TDP1 (0.58) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL922726 0.76 TDP1 (0.58) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL8973475 0.76 TDP1 (0.62) LMNASMN1; SMN2ALDH1A1HTTHPGD
SCHEMBL8964829 0.76 TDP1 (0.62) LMNASMN1; SMN2ALDH1A1HTTHPGD
Hydrogen Sulfide SCHEMBL8071011 0.75 TDP1 (0.57) LMNASMN1; SMN2ALDH1A1HTTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1001766-B1 COMPOUNDS FOR THE TREATMENT OF CCR5-MEDIATED DISEASES SMITHKLINE BEECHAM CORP (US) 2003-04-09 EP disclosed
US-6515027-B1 Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 SMITHKLINE BEECHAM CORP. 2003-02-04 US disclosed
EP-1001766-A4 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORP (US) 2001-04-04 EP disclosed
EP-1001766-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 2000-05-24 EP disclosed
WO-1999001127-A1 COMPOUNDS AND METHODS SMITHKLINE BEECHAM CORPORATION (US) 1999-01-14 WO disclosed